Leonardo DiCaprio and Martin Scorsese are set to relaunch their wonderful working partnership for The Devil in the White City, after Paramount Studios acquired the rights to film Erik Larson’s book of the same name in a big-money deal.

The film will see the powerhouse duo of DiCaprio and Scorsese join forces once again after the critical and commercial success of The Wolf of Wall Street.

According to Deadline, DiCaprio will play one of the most prolific serial killers in Chicago history, the 19th century equivalent of Hannibal Lecter.

“He has wanted this for a long time, but the project’s second wind occurred after Warner Bros let the rights lapse a month ago on the 2003 nonfiction book (Graham Moore was among the writers who did drafts) and came out of conversations with Par’s Brad Grey and Scorsese and Yorn about the studio being at the center of the next DiCaprio-Scorsese teaming; the studio released 2013’s The Wolf Of Wall Street, which got five Oscar nominations,” the US publication wrote.

DiCaprio will play Dr. HH Holmes, a ruthless and prolific serial killer believed to have murdered anywhere from 27 to 200 people at a time when the city of Chicago was enthralled with hosting the World’s Fair of 1893.

Holmes built The World’s Fair Hotel, an inn that has been described as more lethal than the Bates Motel from Psycho, especially for young single women. Holmes used charm and guile to lure guests into what became known as a “murder castle,” a haunt that had a gas chamber, crematorium and a dissecting table where Holmes would murder his victims and strip their skeletons to sell for medical and scientific study. From the sounds of it, the film is going to be extremely gruesome and intense…and we’re all for it!

DiCaprio and Scorsese have already enjoyed wonderful success together, having made Gangs of New York, The Aviator, The Departed, Shutter Island and The Wolf of Wall Street since 2002. Will this finally be the role to bring Leo that elusive Oscar?